Disease Models & Mechanisms Current Issue

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Translating animal models of SARS-CoV-2 infection to vascular, neurological and gastrointestinal manifestations of COVID-19

biologists.com

ABSTRACTSince the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiated a global pandemic resulting...

ABSTRACTSince the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiated a global pandemic resulting in an estimated 775 million infections with over 7 million deaths, it has become evident that COVID-19 is not solely a pulmonary disease. Emerging evidence has shown that, in a subset of patients, certain symptoms − including chest pain, stroke, anosmia, dysgeusia, diarrhea and abdominal pain – all...

Correlative 3D imaging method for analysing lesion architecture in susceptible mice infected with Mycobacterium tuberculosis

biologists.com

ABSTRACTTuberculosis (TB) is characterized by the formation of heterogeneous, immune-rich granulomas in the lungs. Host and...

ABSTRACTTuberculosis (TB) is characterized by the formation of heterogeneous, immune-rich granulomas in the lungs. Host and pathogen factors contribute to this heterogeneity, but the molecular and cellular drivers of granuloma diversity remain inadequately understood owing to limitations in experimental techniques. In this study, we developed an approach that combines passive CLARITY (PACT)-based clearing with light-sheet fluorescence microscopy to visualize lesion architecture and lung involvement...

First person – Caroline Beltran

biologists.com

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers...

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Caroline Beltran is first author on ‘ Correlative 3D imaging method for analysing lesion architecture in susceptible mice infected with Mycobacterium tuberculosis’, published in DMM. Caroline conducted the research described in this article while a...

First person – Meri Uusi-Mäkelä and Sanna-Kaisa Emilia Harjula

biologists.com

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers...

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Meri Uusi-Mäkelä and Sanna-Kaisa Emilia Harjula are joint first authors on ‘ The inflammasome adaptor pycard is essential for immunity against Mycobacterium marinum infection in adult zebrafish’, published in DMM. Meri conducted the research described...

The inflammasome adaptor pycard is essential for immunity against Mycobacterium marinum infection in adult zebrafish

biologists.com

ABSTRACTInflammasomes regulate the host response to intracellular pathogens including mycobacteria. We have previously shown that the...

ABSTRACTInflammasomes regulate the host response to intracellular pathogens including mycobacteria. We have previously shown that the course of Mycobacterium marinum infection in adult zebrafish (Danio rerio) mimics the course of tuberculosis in human. To investigate the role of the inflammasome adaptor pycard in zebrafish M. marinum infection, we produced two zebrafish knockout mutant lines for the pycard gene with CRISPR/Cas9 mutagenesis. Although the zebrafish...

Patient advocacy in tuberculosis research and treatment: an interview with Zolelwa Sifumba

biologists.com

Translational lessons from the balanced immune system in bats

biologists.com

ABSTRACTBats are a natural reservoir for a wide variety of notorious viruses that are deadly to...

ABSTRACTBats are a natural reservoir for a wide variety of notorious viruses that are deadly to humans and other mammals but cause no or minimal clinical damage in bats. The co-evolution of bats and viruses for more than sixty million years has established unique and balanced immune defenses within bats against a number of viruses. With the COVID-19 pandemic, bats have gained greater attention...

A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds

biologists.com

ABSTRACTC9orf72-related amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) has proven difficult to model in mice. Liu et...

ABSTRACTC9orf72-related amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) has proven difficult to model in mice. Liu et al. (2016) reported a bacterial artificial chromosome (BAC) transgenic mouse displaying behavioural, motor and pathological abnormalities. This was followed by multiple laboratories independently refuting and confirming phenotypes. A proposed explanation centred on the use of different FVB background lines (from The Jackson Laboratory and Janvier Labs). We studied...

First person – Sophie Badger

biologists.com

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers...

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Sophie Badger is first author on ‘ A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds’, published in DMM. Sophie conducted the research described in this...

Transcriptional regulation of autophagy in skeletal muscle stem cells

biologists.com

ABSTRACTMuscle stem cells (MuSCs) are essential for the regenerative capabilities of skeletal muscles. MuSCs are maintained...

ABSTRACTMuscle stem cells (MuSCs) are essential for the regenerative capabilities of skeletal muscles. MuSCs are maintained in a quiescent state, but, when activated, can undergo proliferation and differentiation into myocytes, which fuse and mature to generate muscle fibers. The maintenance of MuSC quiescence and MuSC activation are processes that are tightly regulated by autophagy, a conserved degradation system that removes unessential or dysfunctional cellular...

First person – Latifa Bakiri

biologists.com

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers...

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Latifa Bakiri is first author on ‘ A new effLuc/Kate dual reporter allele for tumour imaging in mice’, published in DMM. Latifa is a senior postdoc in the lab of Erwin F. Wagner at Medical...

A new effLuc/Kate dual reporter allele for tumor imaging in mice

biologists.com

ABSTRACTGenetically engineered mouse models (GEMMs) are instrumental for modelling local and systemic features of complex diseases,...

ABSTRACTGenetically engineered mouse models (GEMMs) are instrumental for modelling local and systemic features of complex diseases, such as cancer. Non-invasive, longitudinal cell detection and monitoring in tumors, metastases and/or the micro-environment is paramount to achieve a better spatiotemporal understanding of cancer progression and to evaluate therapies in preclinical studies. Bioluminescent and fluorescent reporters marking tumor cells or their microenvironment are valuable for non-invasive cell...

Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours

biologists.com

ABSTRACTGestational trophoblastic disease (GTD) describes a group of rare benign and cancerous lesions originating from the...

ABSTRACTGestational trophoblastic disease (GTD) describes a group of rare benign and cancerous lesions originating from the trophoblast cells of the placenta. These neoplasms are unconventional entities, being one of the few instances in which cancer develops from the cells of another organism, the foetus. Although this condition was first described over 100 years ago, the specific genetic and non-genetic drivers of this disease remain unknown...

Prostatic Escherichia coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production

biologists.com

ABSTRACTProstate fibrosis contributes to lower urinary tract dysfunction (LUTD). To develop targeted treatments for prostate fibrosis,...

ABSTRACTProstate fibrosis contributes to lower urinary tract dysfunction (LUTD). To develop targeted treatments for prostate fibrosis, it is necessary to identify the cell types and molecular pathways required for collagen production. We used a genetic approach to label and track potential collagen-producing cell lineages in mouse prostate through a round of Escherichia coli UTI89-mediated prostate inflammation. E. coli increased collagen density and production in...

First person – Brandon Scharpf and Hannah Ruetten

biologists.com

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers...

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Brandon Scharpf and Hannah Ruetten are co-first authors on ‘ Prostatic Escherichia coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production’, published in DMM. Brandon is a PhD student in the lab of Dr...

Abca4, mutated in Stargardt disease, is required for structural integrity of cone outer segments

biologists.com

ABSTRACTStargardt disease (STGD), the leading cause of inherited childhood blindness, is primarily caused by mutations in...

ABSTRACTStargardt disease (STGD), the leading cause of inherited childhood blindness, is primarily caused by mutations in the ABCA4 gene; yet, the underlying mechanisms of photoreceptor degeneration remain elusive, partly due to limitations in existing animal disease models. To expand our understanding, we mutated the human ABCA4 paralogues abca4a and abca4b in zebrafish, which has a cone-rich retina. Our study unveiled striking dysmorphology and elongation...

The Company of Biologists: celebrating 100 years

biologists.com

Summary: As we begin celebrating our 100-year anniversary, we reflect on our extraordinary story so far,...

Summary: As we begin celebrating our 100-year anniversary, we reflect on our extraordinary story so far, consider the Company's current support for our communities and prepare for some inspiring activities.